Can I Run Llama 3.1 405B Instruct on a AMD Instinct MI325X?
Runs at Q4_K_M — good quality with reasonable headroom.
1 quant fit your 256GB
| Quant | Min VRAM | Recommended | File size | Headroom |
|---|---|---|---|---|
| Q4_K_MBEST | 246.5 GB | 248.0 GB | 245.5 GB | +9.5 GB |
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FAQ
Can the AMD Instinct MI325X run Llama 3.1 405B Instruct?
Yes. The AMD Instinct MI325X's 256GB of VRAM is enough to run Llama 3.1 405B Instruct at Q4_K_M quantization (246.5GB required).
What's the best quantization to use?
Q4_K_M is the highest-precision quantization that fits in your 256GB. It uses about 246.5GB of memory and 248.0GB recommended for comfortable inference.
What if I need more headroom for context length?
KV cache memory grows with context length. The numbers above assume a baseline 2K-4K context. For long-context use (32K+), add another 2-6GB depending on the model architecture.