Can I Run Mistral Medium 3.5 128B on a AMD Instinct MI300X?
Runs comfortably at Q6_K — minimal quality loss.
4 quantizations fit your 192GB
| Quant | Min VRAM | Recommended | File size | Headroom |
|---|---|---|---|---|
| Q6_KBEST | 106.2 GB | 107.7 GB | 102.6 GB | +85.8 GB |
| Q5_K_M | 91.7 GB | 93.2 GB | 88.3 GB | +100.3 GB |
| Q4_K_M | 78.4 GB | 79.9 GB | 74.9 GB | +113.6 GB |
| Q2_K | 43.0 GB | 44.5 GB | 46.6 GB | +149.0 GB |
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FAQ
Can the AMD Instinct MI300X run Mistral Medium 3.5 128B?
Yes. The AMD Instinct MI300X's 192GB of VRAM is enough to run Mistral Medium 3.5 128B at Q6_K quantization (106.2GB required).
What's the best quantization to use?
Q6_K is the highest-precision quantization that fits in your 192GB. It uses about 106.2GB of memory and 107.7GB recommended for comfortable inference.
What if I need more headroom for context length?
KV cache memory grows with context length. The numbers above assume a baseline 2K-4K context. For long-context use (32K+), add another 2-6GB depending on the model architecture.