Can I Run / Qwen 3.5 122B A10B / on AMD Instinct MI300X
Can I Run Qwen 3.5 122B A10B on a AMD Instinct MI300X?
Yes
Runs at Q8_0 — near-lossless quality.
Model size
122B
GPU memory
192GB
Smallest quant
Q4_K_M
Best fit
Q8_0
4 quantizations fit your 192GB
| Quant | Min VRAM | Recommended | File size | Headroom |
|---|---|---|---|---|
| Q8_0BEST | 130.6 GB | 132.1 GB | 129.6 GB | +61.4 GB |
| Q6_K | 101.5 GB | 103.0 GB | 100.5 GB | +90.5 GB |
| Q5_K_M | 87.6 GB | 89.1 GB | 86.6 GB | +104.4 GB |
| Q4_K_M | 75.0 GB | 76.5 GB | 74.0 GB | +117.0 GB |
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Full model details
Qwen 3.5 122B A10B →
All quant variants, benchmark scores, and use-case tags.
Best models for this GPU
AMD Instinct MI300X →
Top-ranked open-source models that fit in 192GB.
FAQ
Can the AMD Instinct MI300X run Qwen 3.5 122B A10B?
Yes. The AMD Instinct MI300X's 192GB of VRAM is enough to run Qwen 3.5 122B A10B at Q8_0 quantization (130.6GB required).
What's the best quantization to use?
Q8_0 is the highest-precision quantization that fits in your 192GB. It uses about 130.6GB of memory and 132.1GB recommended for comfortable inference.
What if I need more headroom for context length?
KV cache memory grows with context length. The numbers above assume a baseline 2K-4K context. For long-context use (32K+), add another 2-6GB depending on the model architecture.