Can I Run Qwen 3.5 122B A10B on a AMD Instinct MI325X?
Runs at full precision (fp16). Zero quality loss.
5 quantizations fit your 256GB
| Quant | Min VRAM | Recommended | File size | Headroom |
|---|---|---|---|---|
| fp16BEST | 245.0 GB | 246.5 GB | 244.0 GB | +11.0 GB |
| Q8_0 | 130.6 GB | 132.1 GB | 129.6 GB | +125.4 GB |
| Q6_K | 101.5 GB | 103.0 GB | 100.5 GB | +154.5 GB |
| Q5_K_M | 87.6 GB | 89.1 GB | 86.6 GB | +168.4 GB |
| Q4_K_M | 75.0 GB | 76.5 GB | 74.0 GB | +181.0 GB |
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FAQ
Can the AMD Instinct MI325X run Qwen 3.5 122B A10B?
Yes. The AMD Instinct MI325X's 256GB of VRAM is enough to run Qwen 3.5 122B A10B at fp16 quantization (245.0GB required).
What's the best quantization to use?
fp16 is the highest-precision quantization that fits in your 256GB. It uses about 245.0GB of memory and 246.5GB recommended for comfortable inference.
What if I need more headroom for context length?
KV cache memory grows with context length. The numbers above assume a baseline 2K-4K context. For long-context use (32K+), add another 2-6GB depending on the model architecture.