Can I Run Qwen 3.5 397B A17B on a AMD Instinct MI325X?
Runs at Q4_K_M — good quality with reasonable headroom.
1 quant fit your 256GB
| Quant | Min VRAM | Recommended | File size | Headroom |
|---|---|---|---|---|
| Q4_K_MBEST | 241.7 GB | 243.2 GB | 240.7 GB | +14.3 GB |
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FAQ
Can the AMD Instinct MI325X run Qwen 3.5 397B A17B?
Yes. The AMD Instinct MI325X's 256GB of VRAM is enough to run Qwen 3.5 397B A17B at Q4_K_M quantization (241.7GB required).
What's the best quantization to use?
Q4_K_M is the highest-precision quantization that fits in your 256GB. It uses about 241.7GB of memory and 243.2GB recommended for comfortable inference.
What if I need more headroom for context length?
KV cache memory grows with context length. The numbers above assume a baseline 2K-4K context. For long-context use (32K+), add another 2-6GB depending on the model architecture.