Can I Run / Qwen 3.5 Omni Plus / on AMD Instinct MI325X
Can I Run Qwen 3.5 Omni Plus on a AMD Instinct MI325X?
Yes
Runs at Q8_0 — near-lossless quality.
Model size
235B
GPU memory
256GB
Smallest quant
Q4_K_M
Best fit
Q8_0
4 quantizations fit your 256GB
| Quant | Min VRAM | Recommended | File size | Headroom |
|---|---|---|---|---|
| Q8_0BEST | 250.7 GB | 252.2 GB | 249.7 GB | +5.3 GB |
| Q6_K | 194.6 GB | 196.1 GB | 193.6 GB | +61.4 GB |
| Q5_K_M | 167.8 GB | 169.3 GB | 166.8 GB | +88.2 GB |
| Q4_K_M | 143.5 GB | 145.0 GB | 142.5 GB | +112.5 GB |
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Full model details
Qwen 3.5 Omni Plus →
All quant variants, benchmark scores, and use-case tags.
Best models for this GPU
AMD Instinct MI325X →
Top-ranked open-source models that fit in 256GB.
FAQ
Can the AMD Instinct MI325X run Qwen 3.5 Omni Plus?
Yes. The AMD Instinct MI325X's 256GB of VRAM is enough to run Qwen 3.5 Omni Plus at Q8_0 quantization (250.7GB required).
What's the best quantization to use?
Q8_0 is the highest-precision quantization that fits in your 256GB. It uses about 250.7GB of memory and 252.2GB recommended for comfortable inference.
What if I need more headroom for context length?
KV cache memory grows with context length. The numbers above assume a baseline 2K-4K context. For long-context use (32K+), add another 2-6GB depending on the model architecture.