Can I Run Qwen 3 Next 80B A3B on a AMD Instinct MI210?
Runs at Q5_K_M — good quality with reasonable headroom.
11 quantizations fit your 64.0GB
| Quant | Min VRAM | Recommended | File size | Headroom |
|---|---|---|---|---|
| Q5_K_MBEST | 57.8 GB | 59.3 GB | 56.7 GB | +6.2 GB |
| Q5_K_S | 56.2 GB | 57.7 GB | 55.0 GB | +7.8 GB |
| Q5_0 | 56.0 GB | 57.5 GB | 55.0 GB | +8.0 GB |
| Q4_1 | 51.0 GB | 52.5 GB | 50.0 GB | +13.0 GB |
| Q4_K_M | 49.5 GB | 51.0 GB | 48.7 GB | +14.5 GB |
| Q4_K_S | 46.8 GB | 48.3 GB | 46.9 GB | +17.2 GB |
| Q4_0 | 46.0 GB | 47.5 GB | 46.1 GB | +18.0 GB |
| Q3_K_L | 36.6 GB | 38.1 GB | 38.2 GB | +27.4 GB |
| Q3_K_M | 34.5 GB | 36.0 GB | 36.7 GB | +29.5 GB |
| Q3_K_S | 31.8 GB | 33.3 GB | 34.9 GB | +32.2 GB |
| Q2_K | 27.3 GB | 28.8 GB | 28.2 GB | +36.7 GB |
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All quant variants, benchmark scores, and use-case tags.
Top-ranked open-source models that fit in 64.0GB.
FAQ
Can the AMD Instinct MI210 run Qwen 3 Next 80B A3B?
Yes. The AMD Instinct MI210's 64.0GB of VRAM is enough to run Qwen 3 Next 80B A3B at Q5_K_M quantization (57.8GB required).
What's the best quantization to use?
Q5_K_M is the highest-precision quantization that fits in your 64.0GB. It uses about 57.8GB of memory and 59.3GB recommended for comfortable inference.
What if I need more headroom for context length?
KV cache memory grows with context length. The numbers above assume a baseline 2K-4K context. For long-context use (32K+), add another 2-6GB depending on the model architecture.