Can I Run Mistral Medium 3.5 128B on a AMD Instinct MI250X?
Runs comfortably at Q6_K — minimal quality loss.
4 quantizations fit your 128GB
| Quant | Min VRAM | Recommended | File size | Headroom |
|---|---|---|---|---|
| Q6_KBEST | 106.2 GB | 107.7 GB | 102.6 GB | +21.8 GB |
| Q5_K_M | 91.7 GB | 93.2 GB | 88.3 GB | +36.3 GB |
| Q4_K_M | 78.4 GB | 79.9 GB | 74.9 GB | +49.6 GB |
| Q2_K | 43.0 GB | 44.5 GB | 46.6 GB | +85.0 GB |
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Top-ranked open-source models that fit in 128GB.
FAQ
Can the AMD Instinct MI250X run Mistral Medium 3.5 128B?
Yes. The AMD Instinct MI250X's 128GB of VRAM is enough to run Mistral Medium 3.5 128B at Q6_K quantization (106.2GB required).
What's the best quantization to use?
Q6_K is the highest-precision quantization that fits in your 128GB. It uses about 106.2GB of memory and 107.7GB recommended for comfortable inference.
What if I need more headroom for context length?
KV cache memory grows with context length. The numbers above assume a baseline 2K-4K context. For long-context use (32K+), add another 2-6GB depending on the model architecture.