GPU GUIDE · AMD
Best AI models for the
AMD Instinct MI250X
The AMD Instinct MI250X has 128GB of VRAM. Below are the top 30 open-source AI models that fit, ranked by composite benchmark score. Each row shows the best quantization that fits your hardware.
VRAM
128GB
Brand
amd
Models that fit
30
Generation
Instinct
Top 30 models for the AMD Instinct MI250X
01
77.5DeepSeek V4 Flash
37.0BBest fit: fp16 · 75.0GBCan I run it? →
02
76.4Qwen 3.6 27B
27.0BBest fit: fp16 · 55.0GBCan I run it? →
03
74.9MiMo V2 Omni
120BBest fit: Q6_K · 99.8GBCan I run it? →
04
72.5Qwen 3.6 35B A3B
35.0BBest fit: fp16 · 71.0GBCan I run it? →
05
70.1Qwen3.5-27B
27.8BBest fit: f32 · 112.2GBCan I run it? →
06
69.3Qwen 3.5 122B A10B
122BBest fit: Q6_K · 101.5GBCan I run it? →
07
65.4Mistral Medium 3.5 128B
128BBest fit: Q6_K · 106.2GBCan I run it? →
08
65.3Gemma 4 31B (free)
31.0BBest fit: fp16 · 63.0GBCan I run it? →
09
61.9Qwen 3.5 35B A3B
35.0BBest fit: fp16 · 71.0GBCan I run it? →
10
59.9NVIDIA Nemotron 3 Super 120B A12B BF16
124BBest fit: Q6_K · 102.8GBCan I run it? →
11
55.4GPT-OSS 120B
120BBest fit: Q6_K · 99.8GBCan I run it? →
12
54.0Qwen 3.5 9B
9.0BBest fit: fp16 · 19.0GBCan I run it? →
13
53.8gemma 4 31B
32.7BBest fit: fp16 · 66.4GBCan I run it? →
14
52.0Gemma 4 26B A4B (free)
26.5BBest fit: f32 · 107.0GBCan I run it? →
15
45.1Qwen 3.5 4B
4.0BBest fit: fp16 · 9.0GBCan I run it? →
16
45.0Qwen 3 Next 80B A3B
80.0BBest fit: Q8_0 · 86.0GBCan I run it? →
17
44.5Qwen3 Next 80B A3B Thinking
81.3BBest fit: Q8_0 · 87.4GBCan I run it? →
18
40.8GPT-OSS 20B
20.0BBest fit: fp16 · 41.0GBCan I run it? →
19
40.5Nemotron 3 Nano 30B A3B (free)
31.6BBest fit: Q8_0 · 34.6GBCan I run it? →
20
37.4Qwen3 30B A3B Thinking 2507
30.5BBest fit: Q8_0 · 33.4GBCan I run it? →
21
36.7Devstral 2
24.0BBest fit: fp16 · 49.0GBCan I run it? →
22
35.7Nemotron 3 Nano Omni 30B A3B Reasoning BF16
30.0BBest fit: fp16 · 61.0GBCan I run it? →
23
33.3Qwen3 Coder 30B A3B Instruct
30.5BBest fit: Q8_0 · 33.4GBCan I run it? →
24
32.9QwQ 32B
32.0BBest fit: fp16 · 65.0GBCan I run it? →
25
32.8Qwen3 VL 30B A3B Thinking
31.1BBest fit: f32 · 125.4GBCan I run it? →
26
33.5Qwen3 Next 80B A3B Instruct (free)
81.3BBest fit: Q4_K_M · 50.3GBCan I run it? →
27
32.4Devstral Small 2 24B Instruct 2512
24.0BBest fit: f32 · 97.0GBCan I run it? →
28
31.7Devstral Small 2
7.0BBest fit: fp16 · 15.0GBCan I run it? →
29
31.3Mistral Medium 3.5
70.0BBest fit: Q8_0 · 75.4GBCan I run it? →
30
31.3gemma 4 E4B it
8.0BBest fit: f32 · 33.0GBCan I run it? →
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FAQ — running AI on the AMD Instinct MI250X
How many AI models can the AMD Instinct MI250X run?
With 128GB of VRAM, the AMD Instinct MI250X can run 30+ open-source models from our database, including DeepSeek V4 Flash, Qwen 3.6 27B, MiMo V2 Omni.
What's the largest LLM I can run on a AMD Instinct MI250X?
The biggest model that fits is approximately 128B. Larger models would need to be quantized further or won't fit at all.
Is 128GB of VRAM enough for local AI?
Yes — 128GB comfortably runs most popular open-source models including 30B-class LLMs at Q4_K_M.